| abstract |
The Cinnamomi Twig and Moutan Root Bark, Glue and Peony Root, or the mixture of Ganoderma lucidum and Poria extract of the present invention inhibit excessive final glycation products from occurring in the chronic diabetic state, The present invention relates to an agent for inhibiting the production of endogenous glycoprotein in a human retinal pigment epithelial cell line which exhibits cross-linking activity of a glycoprotein and a substrate protein and is in a hyperglycemic environment or an aging environment, and exhibits various diabetic complication animal models, By confirming that the animal model has excellent effects of delaying, preventing and treating diabetic complications and macular degeneration, retinal edema and lower limb edema, the mixed extract can be used for diabetic complications including diabetic retinopathy, diabetic nephropathy and diabetic neuropathy diabetic complications and prevention and management of angioedema including macular (retinal) edema, macular degeneration and lower limb varices Can be usefully used as an effective ingredient of a composition for medical use. |