| abstract |
Time dilution release-release solid tablet comprising benzonate in a matrix with at least one pharmaceutically acceptable modified release pH-independent material to provide a 12-hour deformation-release profile to the < RTI ID = 0.0 > Capsules that do not substantially release benzonate from tablets or capsules in the mouth and release less than about 25% of the benzonate in less than 1 hour when measured by in vitro dissolution assay, Tablets or capsules are described. Modified release can be achieved by (a) a high melting temperature, a water insoluble wax or waxy substance, (b) a low viscosity hydrophilic polymer such as hydroxypropylmethylcellulose, (c) a reverse-enteric coating, Can be provided. Benzonatate can be present in adsorbent materials with silico or silicates or in complexes with weakly acidic ion exchange resin complexes. |