abstract |
In one aspect, the invention provides a first variant Fc domain comprising a first variant Fc domain comprising a first heavy chain constant domain comprising a first variant Fc domain and a first antigen binding domain, and a second heavy chain comprising a second variant Fc domain and a second antigen binding domain, Lt; RTI ID = 0.0 > monoclonal < / RTI > domain. In a further embodiment, the heterodimeric antibody comprises a first monomer comprising a heavy chain comprising a first Fc domain and a single chain Fv region (scFv) that binds to a first antigen, wherein the scFv comprises a charged scFv linker . The heterodimeric antibody further comprises a second monomer comprising a first heavy chain comprising a second Fc domain and a first variable heavy chain and a first light chain. |