| abstract |
The present invention relates to 2,5,6,7-quadrivalent thiazolo [4,5-b] pyridine derivatives represented by the following formula (1) and useful for vascular inflammation-related infectious diseases caused by the HMGB1 protein activity containing the 2,5,6,7- Lt; / RTI > The 2,5,6,7-quadro-substituted thiazolo [4,5-b] pyridine derivatives of the present invention were found to increase the survival rate of sepsis as a result of searching for anti-septic effects through CLP- A vascular inflammatory disease including sepsis caused by HMGB1 protein activity, which comprises the 2,5,6,7-quadro-substituted thiazolo [4,5-b] pyridine derivative or a pharmaceutically acceptable salt thereof as an active ingredient and It can be usefully used as a therapeutic agent for infectious diseases. |