http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150117028-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b3e3de86fb3a7d008414342c8035051 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a796677cc43a87926cc99919df0cf603 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b16ceb49b9b1d25d9ebbec574d3cef3e |
| publicationDate | 2015-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20150117028-A |
| titleOfInvention | The pharmaceutical compositions for prevention or treatment of JMJD-related diseases containing clioquinol or its derivatives as a active ingredient |
| abstract | The present invention provides a pharmaceutical composition or a kit for inhibiting JMJD enzyme activity for the prevention and treatment of JMJD-related diseases comprising clinoquinol or a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient. Also provided is a method for inhibiting the enzyme activity of JMJD by treating a pharmaceutically effective amount of a quinoquinol or a derivative thereof and a method for screening a JMJD modulator. In the present invention, the expression of various JMJD genes is increased upon treatment with the quinoquinol or a derivative thereof, but the amount of methylated histone is increased by suppressing the demethylating enzyme activity of the JMJD proteins. Such a composition containing a quinoquin or a derivative thereof inhibiting JMJD protein activity may be useful as a therapeutic agent for JMJD-related diseases, particularly cancer, autoimmune diseases or osteoporosis. |
| priorityDate | 2014-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 191.