http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150116244-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ceacc0d4ea78a0c031481ea91ead628 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2014-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53fd63213266f7b46e0049c4b21bb035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe98988d41bf4c64058a2e6a4e8914f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bde03e8fd9809a7000cf0cf70857964b |
| publicationDate | 2015-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20150116244-A |
| titleOfInvention | Pharmaceutical composition for inhibiting proliferation and metastasis of breast cancer containing AHCY expression or activity inhibitor |
| abstract | S-adenosylhomocysteine hydrolase (AHCY) hydrolyzes S-adenosyl homocysteine to adenosine and L-homocysteine and is well known as a potential therapeutic target for cancer, malaria and viral diseases. We have identified the molecular mechanism of AHCY for breast cancer. The role of AHCY in breast cancer proliferation and metastasis was evaluated using a stable cell line by XTT analysis, wound healing assay and transwell assay. Thus, we found that AHCY is related to the malignant effect of breast cancer cells and the cell cycle by regulating ERK cell signaling pathways. To investigate the role of AHCY in in vivo, we examined the development of mammary gland in AHCY knockout mice by wire staining, confirming that mammary gland growth was affected by AHCY deficiency. Taken together, we have shown that AHCY participates in the regulation of breast cancer proliferation and metastasis by the ERK cell signaling pathway. |
| priorityDate | 2014-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 569.