| abstract |
This document describes the synthesis of a class of gem-difluoronated c-glycoside compounds derived from grape philatoxin, including, but not limited to, those used in oncology for cancer therapy. More specifically, the grape pylotoxin gem-difluorinated cation-glycosoconjugated derivatives exhibit improved satiation and chemical stability, and improved cytotoxicity against drug-resistant cancer cell lines. |