| abstract |
The present invention relates to methods of treating cancer in humans, and pharmaceutical combinations useful in such treatment. In particular, the process involves the coupling of 2-methyl-1 - {[2-methyl-3- (trifluoromethyl) phenyl] methyl} -6- (4-morpholinyl) -1H-benzimidazole- Or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable salt of N- {3- [3-cyclopropyl-5- (2-fluoro-4-iodo-phenylamino) 6,8-dimethyl- -3,4,6,7-tetrahydro-2H-pyrido [4,3-d] pyrimidin-1-yl] phenyl} acetamide or a pharmaceutically acceptable salt or solvate thereof, To a human being. |