abstract |
6H3 ", an antigen-binding fragment thereof, a derivative thereof, and a humanized mutant thereof, and an anti-human B7-H4 antibody capable of specifically binding to B7-H4 in the treatment and diagnosis of cancer and other diseases, do. In a preferred embodiment, the molecule is capable of inhibiting tumor growth, preventing tumor growth and / or inhibiting tumor growth and / or inhibiting the activity of tumor-associated macrophages (" TAM ") Block or deplete to alter their activity and / or lower TAM mediated immunosuppression. |