| abstract |
The invention disclosed herein relates to compounds of formula I and their pharmaceutically acceptable salts useful for the treatment of prostate cancer, breast cancer, colon cancer, pancreatic cancer, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also encompasses pharmaceutical compositions comprising a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof. In addition, the invention disclosed herein relates to a method of treating prostate cancer, breast cancer, ovarian cancer, liver cancer, renal cancer, colon cancer, pancreatic cancer, human chronic lymphocytic leukemia, melanoma and other cancers. In addition, the invention disclosed herein relates to a method of treating prostate cancer, breast cancer, colon cancer, pancreatic cancer, chronic lymphocytic leukemia, melanoma, and other cancers, comprising administering a therapeutically effective amount of a selective PPARa antagonist. The compounds and pharmaceutical compositions of the present invention are also useful in the treatment of viral infections such as HCV infection and HIV infection. |