| abstract |
This application sequence coupled to a protein and the coiled coil domain, with a coiled coil domain 1: ZXBBBBZ (wherein · Z is either any amino acid or absent; · X is any amino acid; · B is arginine (R) Or a lysine (K)). ≪ / RTI > The modified protein is an antigen or carrier protein, in particular, associated with an antigen. These modified proteins have increased affinity for negatively charged polymers such as nucleic acids or heparin and exhibit increased immunogenicity. |