| abstract |
The present invention provides antibodies, antigen-binding antibody fragments (Fab), and other protein scaffolds for human activated protein C (aPC) that binds at least to a zymogen protein C (PC). In addition, such aPC binding protein can induce clotting by potentially blocking the anticoagulant activity of aPC. Therapeutic uses of such binders are described herein as methods for panning and screening specific antibodies. |