http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150085513-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e13cf25eb1bef6199475314477618b46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-94 |
| filingDate | 2013-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ae9dd3d4af1e1e81486eba54baf4508 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b2910b13b32682be2175898e7c76ec1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_846f052a949dbbc782fb87b73b3103a3 |
| publicationDate | 2015-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20150085513-A |
| titleOfInvention | Process for the preparation of (1s,4s,5s)-4-bromo-6-oxabicyclo[3.2.1] octan-7-one |
| abstract | The present invention relates to a compound useful as a prophylactic and / or therapeutic drug for thrombotic diseases and exhibiting an inhibitory effect on activated blood coagulation factor X (also referred to as activation factor X or FXa) (1S, 4S, 5S) -4-bromo-6-oxabicyclo [3.2.1] octan-7-one represented by the following formula . The process comprises reacting (1S) -cyclohex-3-ene-1-carboxylic acid of formula (II) with dichloromethane, toluene, tetrahydrofuran, ethyl acetate, hexane, cyclopentyl methyl ether (CPME) Bromo succinimide or 1,3-dibromo-5,5-dimethylhydantoin in the presence of a base selected from calcium oxide or calcium hydroxide in a solvent selected from the group consisting of To obtain (1S, 4S, 5S) -4-bromo-6-oxabicyclo [3.2.1] octan-7-one of formula (I). |
| priorityDate | 2012-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.