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filingDate 2014-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aeae8b43a90d93c0d8400383e6429407
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publicationDate 2015-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20150082968-A
titleOfInvention A promoter variant and a method for protein production using the same
abstract The present invention is Bacillus Chuo ringen sheath (Bacillus thuringiensis , Bt) promoter mutant comprising a UP element at the upper part of a Cry3Aa promoter, and a promoter mutant for increasing expression of a downstream target gene. More specifically, the present invention relates to a promoter variant that increases the expression of a sub-target protein by adding a nucleotide sequence enriched in nucleotide adenine (A) and thymine (T) to an upper region of the -35 region of the Cry3Aa promoter. When the expression system of the present invention is used, the expression of the target protein in the Bacillus strain can be markedly increased, and it is possible to efficiently produce proteins industrially useful as well as biotechnology, medicine and the like through mass production of target proteins such as proteins and polypeptide drugs Can be used.
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