http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150072113-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b4be2300a741a69aa1b8bb47a88899f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 2013-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf61c8be64b05ae30498b3b01b0840f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_660b7b52bd50ed29c5c125b29e93bf32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e843cf5b682aa811ebfa4f8942298a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_355519639235753bec2b3678bb4ff5e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea5679a75f399ac43ab86a1d51a52b69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3be81ff1493c1f27af06f401dc5febf4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_015f184ac56318d8bdf787861e1c3d52 |
| publicationDate | 2015-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20150072113-A |
| titleOfInvention | Pharmaceutical composotion for treating ischemia containing cell-transducible Atox1 fusion protein |
| abstract | Atox1 (Antioxidant-1), also referred to as HAH1, has antioxidant protection that regulates copper homeostasis and protects cells from toxic effects produced by superoxide anions and hydrogen peroxide. However, the biological function of Atox1 is unknown in pre-cerebral ischemia. The present inventors have found that the Atox1 fusion protein has a cytoprotective effect against oxidative stress induced neuronal apoptosis in vitro and a protective effect against an ischemic animal model in invivo. The Atox1 fusion protein effectively penetrates into neurons in a concentration- and time-dependent manner. The intracellular Atox1 fusion protein increased the cell survival rate to hydrogen peroxide toxicity and decreased the intracellular reactive oxygen species level and hydrogen peroxide induced DNA fragmentation. In the animal model, Atox1 fusion protein showed protective effect against neuronal cell death induced by transient ischemia in the CA1 part of the whole hippocampus. These results indicate that Atox1 fusion protein has a protective effect against apoptosis and has a therapeutic effect for protecting nerve cells from damage of cerebral ischemia. |
| priorityDate | 2013-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 305.