| abstract |
The present invention relates to compounds of the general formula (I), or pharmaceutically acceptable salts thereof, wherein: (I) In this formula, X, Y, Z, R 1 , R 2 , R 3 and R 3 ' are as defined in the specification and claims. The present invention also relates to a process for the preparation and use of the compounds of formula I as well as to pharmaceutical compositions containing such compounds. The compounds of formula I are LMP7 inhibitors and may be useful in the treatment of related inflammatory diseases and diseases such as rheumatoid arthritis, lupus and irritable bowel disease. |