| abstract |
This disclosure is directed to compositions comprising a cross-linked cation-binding polymer comprising a carboxylic acid group and a monomer containing a pKa reducing group, generally comprising an electron withdrawing substituent, such as a halide atom ( e.g. , fluorine) The polymer optionally containing less than about 20,000 ppm non-hydrogen cations and the base being present in an amount sufficient to provide an equivalent of about 0.2 to about 0.95 equivalents of base / carboxylic acid groups of the polymer. The present disclosure also relates to methods of making the compositions and methods of using the compositions to treat various diseases or disorders. |