| abstract |
The present invention provides quick-acting tablets and the like which are excellent in binding property and disintegrability and excellent in storage stability. Specifically, it is a composite granule comprising at least a low-substituted hydroxypropyl cellulose having a substitution degree of hydroxypropoxy group of 5 to 16 mass% and D-mannitol, wherein D-sorbitol A content of 0.9 mass% or less, a complex granule, and a drug, at least a low-substituted hydroxypropyl cellulose having a substitution degree of hydroxypropoxy group of 5 to 16 mass% By weight of D-mannitol and water to obtain an aqueous dispersion, and a granulation step of granulating the obtained aqueous dispersion by adding it to the second D-mannitol. And a total content of D-sorbitol in the second D-mannitol is 0.9 mass% or less. |