| abstract |
The novel indan sulfamide compounds, such as N - [a (1 S) -2,2,5,7- tetrahydro-fluoro-2,3-dihydro -1 H - inden-1-yl] sulfamide, N - [ (1S) -2,2,4,7-tetrafluoro-2,3-dihydro- 1H -inden-1-yl] sulfamide and (+) - N- 7-pentafluoro-2,3-dihydro- 1H -inden-1-yl) sulfamide, or a pharmaceutically acceptable salt thereof, has an action to improve seizure severity (score) in the mouse Kindling model Therefore, it is expected as a drug for treating epilepsy. |