| abstract |
One to four incretin receptor ligand polypeptides and a mutation in which the amino acid residue at position 329 is a different residue and a group comprising amino acid residues at positions 228, 233, 234, 235, 236, 237, 297, 318, 320, 322 and 331 An Fc-region fusion polypeptide or Fc-region junction comprising a mutant human Fc-region having at least one additional mutation wherein at least one amino acid selected from SEQ ID NO: 2 is a different residue is reported herein, wherein the residue in the Fc- It is numbered according to Kabat's EU index. |