| abstract |
The present invention provides novel dihydroorotate dehydrogenase inhibitors applicable to various diseases. (I) as an active ingredient, (Wherein, X represents a halogen atom, R 1 represents a hydrogen atom, R 2 represents an alkyl group having 1 to 7 carbon atoms, R 3 represents -CHO, R 4 is, -CH 2 -CH = C (CH 3) -R 0 ( wherein, R is 0, the terminal carbon and / or non-terminal may have a substituent on the carbon of an alkyl group having 1 to 12 carbon atoms in the , An alkenyl group having 2 to 12 carbon atoms which may have a substituent on the carbon atom at the terminal and / or non-terminal carbon, or a carbon atom having 2 to 12 carbon atoms which may have a substituent on the terminal carbon atom and / An alkynyl group) , An optical isomer thereof and a pharmaceutically acceptable salt thereof have excellent dihydroxyorotate dehydrogenase inhibiting activity and are useful as immunosuppressive agents, rheumatic therapeutic agents, anticancer agents, rejection response drugs, antiviral agents, And can be used as a pills and diabetes remedy. |