| abstract |
The present invention relates to a TNF-? / CXCL-10 dual target antibody based on an IgG format, specifically a scFv having a heavy chain variable region and a light chain variable region of a CXCL10 specific antibody is reacted with a heavy chain constant region C- By confirming that the antibody bound in its terminal form is a bispecific antibody that effectively binds both to TNF-? And CXCL10, the antibody can be usefully used as a double-target antibody capable of recognizing TNF-? / CXCL10. The composition of the present invention includes a TNF-α / CXCL-10 dual target antibody that binds effectively to both tumor necrosis factor-alpha (TNF-α) and CXCL10 (C-X-C motif chemokine 10). The dual target antibodies of the present invention have superior TNF-a inhibitory and osteoclast differentiation inhibitory potency as compared to TNF-a or CXCL10 single target antibodies. The composition of the present invention can be used for prevention or treatment of immune diseases. |