| abstract |
The present invention relates to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of the present invention relates to the antibodies and binding fragments thereof described herein, which include the sequences of the V H , V L and CDR polypeptides described herein and the polynucleotides encoding the sequences. The invention also contemplates the conjugation of an anti-PCSK9 antibody conjugated to one or more functional or detectable moieties and binding fragments thereof. The present invention also contemplates a method of producing said anti-PCSK9 antibody and a binding fragment thereof. Embodiments of the invention also belong to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, evaluation and treatment of diseases and disorders associated with PCSK9. |