| abstract |
Semi-synthetic rapamycin analogs having a triazole moiety or a pharmaceutically acceptable salt or prodrug thereof are cytostatic agents and mTOR inhibitors of broad efficacy and are useful in the treatment of kidney, liver, breast, head, lung, It is useful for the treatment of various cancers or tumors in organs such as the prostate gland, and recurrent stenosis in the coronary arteries, peripheral arteries, cerebral arteries, immune and autoimmune diseases. Also provided are methods of inhibiting fungal growth, restenosis, posttransplant tissue rejection, and compositions that inhibit immune and autoimmune disease and cancer, fungal growth, recanalization, graft rejection, and immune and autoimmune diseases in a mammal / RTI > Particularly preferred applications of such triazole-containing rapamycin analogues are treatment of renal, lung, colon, and breast cancer, wherein the efficacy of the drug, its half life, tissue distribution characteristics, and bioavailability through the oral and venous route Its pharmacokinetic properties are essential for clinical outcome. |