abstract |
The present disclosure provides antibodies that specifically bind to chalidine or des-Arg10-calhidine. The present disclosure also provides nucleic acids encoding anti-collidine or des-Arg10-caldin antibodies, recombinant expression vectors for producing such antibodies or fragments thereof, as well as host cells as well as pharmaceutical compositions. Also provided by the present invention is a method of using an antibody of the disclosure to modulate cholidine or des-Arg10-calibrin activity in vivo or in vitro or to detect a cholidine or des-Arg10-calibrin. The present disclosure also provides methods for preparing antibodies that specifically bind to des-Argg-bradykinin and des-Arg 10 -caldine-like peptides. |