| abstract |
The present invention relates to a biaryl derivative of the following formula 1, a method for preparing the same, a pharmaceutical composition containing the same, and a use thereof. The biaryl derivative according to the present invention is a GPR120 agonist, which promotes GLP-1 production in the gastrointestinal tract, It is useful for the prevention and treatment of metabolic diseases such as diabetes, complications of diabetes, obesity, nonalcoholic fatty liver, fatty liver, osteoporosis, inflammation, and the like by improving anti-inflammatory action in macrophages and adipocytes and improving insulin resistance in liver and muscles. . [Chemical Formula 1] Wherein A, B, D, E, G, R 1 , R 2 , R 3 , R 4 , R 7 , m and n are as defined in the specification. |