| abstract |
The present disclosure provides methods and materials related to the manufacture and use of liquid vaccines for oral administration. For example, the composition may be formulated into a freeze-dried or dried vaccine component (e.g., a lyophilized pathogen, such as a lyophilized rotavirus preparation) and a liquid edible oil composition (e. G., A liquid edible composition containing one or more medium chain triglycerides Oil compositions), and methods of making and using the liquid vaccines for oral administration and materials therefor are provided. In some cases, liquid vaccine formulations comprising a buffer component (e.g., CaCO 3 ) are provided. |