| abstract |
The present invention relates to N-hydroxysulfonamide derivatives which donate nitroxyl (HNO) under physiological conditions and which are useful for the treatment of the onset and / or progression of diseases or disorders responsive to nitroxyl therapy including heart failure and ischemia / reperfusion injury / RTI > and / or < / RTI > The novel N-hydroxysulfonamide derivatives release NHO at controlled rates under physiological conditions, and the rate of HNO release is regulated by changing the nature and location of the functional groups of the N-hydroxysulfonamide derivatives. [Index] Nitroxyl donor, hydroxylsulfonamide, heart failure, ischemia, reperfusion |