| abstract |
Fused aromatic phosphonates of formula I are precursors to inhibitors of protein tyrosine phosphatase-1B (PTP-1B). Formula I Accordingly, the compounds of the present invention are useful for treating disorders, conditions or diseases responsive to the inhibition of protein tyrosine phosphatase-1B in mammals, including type 2 diabetes, insulin resistance, lipid disorders, obesity, metabolic syndrome and cancer . |