abstract |
The present invention relates to a process for producing CMP-N-acetylneuraminic acid using N-acetyl-D-glucosamine in a single reactor and a process for producing a sialic acid (neuraminic acid) derivative which binds sialic acid to galactose or a galactose derivative And a process for producing a sialic acid derivative. According to the present invention, it is possible to recycle expensive cytidine 5'-phosphate (CMP) in a reaction vessel, thereby reducing the amount of cytidine 5'-phosphate (CMP) -D-glucosamine and pyruvic acid as a substrate, a sialic acid derivative can be produced, and a sialic acid derivative can be produced with higher efficiency. |