abstract |
The present invention relates to an anti-obesity composition using an acetylation inhibitor of malate dehydrogenase 1 (MDH1). More particularly, MDH1 increases the expression of MDH1 during adipocyte differentiation, , The lysine acetylation level of the MDH1 protein is rapidly increased and the activity of the MDH1 protein is increased. Thus, the MDH1 acetylation inhibitor is useful as an active ingredient in a pharmaceutical composition for anti-obesity and adipocyte differentiation inhibition . |