http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20140135634-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fe76949cd566430d9d83a068bab21e1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57419 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate | 2014-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e313dd93a6ba4e01e05dc35b8087090 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5377bf90b2092baf81664af283893e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69a9f1923e6a1fa2a7b18cddb10b4d79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b66b6fbe51b72e8069d5dade4bb2e9b |
| publicationDate | 2014-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20140135634-A |
| titleOfInvention | Screening method for metastasis inhibitor of cancer using cell or spheroid cell mass regulated expression of lysyl-tRNA synthetase in 3-dimensional collagen gels environments |
| abstract | The present invention relates to a method for screening for cancer metastasis inhibitor and a method for screening for cancer metastasis inhibitor and a cancer cell from a cancer cell mass, The present invention relates to a method for monitoring epithelial-mesenchymal transition, migration, invasion and metastasis. More particularly, the present invention relates to a method for monitoring epithelial-mesenchymal transition, migration, invasion and metastasis using various cell lines including HCT116 cell line, Incomplete epithelial-mesenchymal transition phenotype (incomplete ECM phenotype) was induced in a cell line inhibiting KRS expression when cultured in a two-dimensional environment, Inhibition of extracellular matrix (ECM) attachment and cell-ECM signaling activity It was cut. In addition, KRS expression inhibition induces mesenchymal cells when cultured in a water-soluble environment or in a three-dimensional collagen gel culture environment, but the cell-cell adhesion injury And inhibits cell-ECM attachment and related signaling activity, thereby inhibiting dissemination from spheroid cells cultured in a three-dimensional collagen gel culture environment, , It is possible to screen cancer metastasis inhibitors and to monitor the migration, invasion and metastasis of cancer cells, and it is possible to produce low cost, high efficiency added value in preclinical experiments necessary for drug development Which is one of the screening methods. |
| priorityDate | 2013-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 375.