| abstract |
The present invention relates to a composition for diagnosing sepsis using TGFBI, a pharmaceutical composition for preventing or treating septicemia using the composition, and a method for screening the same. More particularly, the present invention relates to a method for screening a composition for prevention and treatment of sepsis using TGFBI protein expression level, A composition for treating sepsis, a composition for diagnosing sepsis including an agent for measuring TGFBI protein expression level, a diagnostic kit, a diagnostic method, and the like. TGFBIp is markedly elevated when sepsis develops. Reducing the expression of TGFBIp can reduce the mortality due to sepsis and the permeability of vascular endothelial cells. Therefore, a therapeutic agent for sepsis can be selected using TGFBIp, a pharmaceutical composition for preventing or treating sepsis can be prepared using TGFBIp inhibitor, and the expression level of TGFBI protein is effective for diagnosis of sepsis. |