| abstract |
The present invention is particularly directed to antibodies having increased ADCC activity. It also provides a method for producing such antibodies. The antibodies of the present invention are produced in mammary epithelial cells such as mammary epithelial cells of non-human transgenic animals engineered to express and secrete antibodies in its milk. Compositions comprising the antibodies or antibodies can be used to treat diseases with the benefits provided by ADCC activity. Thus, in one embodiment, compositions comprising antibodies or antibodies can be used to treat cancer, lymphoproliferative disorders or autoimmune diseases. |