| abstract |
The present invention relates to a protein conjugate in which an oxytomodulin and an immunoglobulin Fc region are linked through a nonpeptide polymer, and a pharmaceutical composition for preventing or treating obesity comprising the conjugate. The conjugate comprising the auxin tomodulin and the immunoglobulin Fc of the present invention shows no adverse effect similar to the auxin tomodulin and can be used to reduce the food intake, And exhibits superior receptor activating effect and long-term sustainability over oxytomodulin, it can be widely used for safe and effective treatment of obesity. |