| abstract |
The present invention relates to a composition for the prevention or treatment of immune diseases comprising metformin and coenzyme Q10, which are used for preventing or treating immune diseases caused by abnormality of immune response, as an active ingredient. The combination administration of metformin and coenzyme Q10 according to the present invention has an effect of inhibiting the expression of the inflammatory cytokines TNF-a, IL-6, IL-17, IFN-y and / Lt; RTI ID = 0.0 > osteoclast < / RTI > differentiation or inhibit the infiltration of inflammatory cells. In addition, the composition of the present invention has an effect of improving weight loss caused by inflammatory bowel disease, has an effect of regulating the activity of IgG of pathologic B cells, inhibits the expression of inflammatory cytokines, inhibits the expression of Foxp3 + Treg Activity can be effectively utilized as a composition for preventing or treating various immune diseases such as inflammatory bowel disease, lupus, graft versus host disease, and the like. |