| abstract |
The present invention relates to a combination preparation comprising clopidogrel and aspirin, which comprises granules coated with a clopidogrel layer as an immediate-release layer and aspirin granules coated with an enteric layer in an encapsulated capsule. The present invention provides a method for preventing the closure of clopidogrel and aspirin by blocking the eutectic phenomenon and preventing the change of the drug content, the elution property and the bioequivalence in the short term, In addition, it has an effect of preventing the gastric wall injury by coating the aspirin with the enteric layer. In order to improve the stability of clopidogrel and its salts which are sensitive to moisture, the production of clopidogrel flexible substance was minimized without changing the elution amount of clopidogrel, including the moisture proof coating base material. |