| abstract |
It is an object of the present invention to provide a novel compound useful as an anticancer drug capable of orally administrable with excellent Aurora A selective inhibitory action and further to provide a novel antitumor effect enhancer and a combination therapy of a microtubule action drug including a taxane- . The compound of formula (I) (Wherein R 1 represents a carboxyl group, -C (= O) NR 5 R 6 , or an oxadiazolyl group which may have a C 1 -C 6 alkyl group or a trifluoromethyl group as a substituent; R 2 represents a halogen represents an atom or a C 1 -C 6 alkoxy; R 3 is a halogen atom, C 1 -C 6 alkyl, C 1 -C 6 alkoxy group and trifluoromethyl with the same or different groups selected from a methyl group as a substituent 1 to 3 R 4 represents a hydrogen atom or a C 1 -C 6 alkyl group; R 5 and R 6 are the same or different and each represents a hydrogen atom, a C 1 -C 6 alkyl group or a C 3 -C 6 alkyl group; And R 5 and R 6 may be taken together with the nitrogen atom to which they are bonded to form a nitrogen-containing saturated heterocyclic group of 3 to 6 atoms. |