| abstract |
Benzimidazoles of formula (I), and pharmaceutically acceptable salts thereof, as inhibitors of RSV, can be used to treat or prevent RSV infection: In formula (I) In the above formula (I), A is a substituted or unsubstituted 5-to 12-membered aryl or 5-to 12-membered heteroaryl; Y is a single bond, - (CH 2 ) p -, -X-, -CH 2 -X-, or -X-CH 2 -; X is -O-, -S-, -N (R 2 ) -,> C = O,> S (= O),> S (= O) 2, -OC (= O) -, -C (= O) -O-, -N (R 2 ) -C (= O) -, or -C (= O) -N (R 2 ) -; Each L is independently a single bond, C 1-3 alkylene, C 2-3 alkenylene or C 2-3 alkynylene; R 1 is each independently unsubstituted or substituted C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; Each Z is independently -N (R 2 ) 2 , -OR 2 , -SR 2 , -S (= O) R 2 , -S (= O) 2 R 2 ; Each R 2 is independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, or C 2-6 alkynyl, wherein the alkyl, alkenyl, and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2 or 3; n is 1, 2 or 3; And p is 1, 2 or 3; |