abstract |
The present invention provides a transgenic non-human animal comprising a nucleic acid encoding an immunoglobulin light chain, wherein the immunoglobulin light chain is a human, human-like, or humanized light chain. The nucleic acid is provided with a means for making it resistant to DNA rearrangement and / or somatic hypermutation. In one embodiment, the nucleic acid comprises an expression cassette for expressing a molecule of interest in a cell during a particular developmental stage within a cell that develops into a mature B cell. The present invention further provides a method for producing immunoglobulins from transgenic non-human animals. |