| abstract |
The present invention is a symmetric bispecific antibody of class IgG4 comprising two heavy chains each comprising a variable domain, a C H 1 domain and a hinge region, wherein in each heavy chain, a C The cysteine of the H 1 domain is replaced by another amino acid; Optionally, one or more of the amino acids located in the upper hinge region are replaced by cysteine, the constant region sequences of each heavy chain are similar or identical, and the variable regions of each heavy chain are different. And to a method for producing the antibody and the formulation. |