| abstract |
The present invention relates to a compound according to formula (A) or a pharmaceutically acceptable salt or solvate thereof. A In the above formula (A) n is 1 or 2; R 1 and R 2 are independently hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy, CD 3 or halogen; R 3 is hydrogen, C (= O) OR 7, or C 1-4 alkyl optionally substituted with hydroxy or NR 8 R 9; R4 is hydrogen or oxo; R5 and R6 are independently, hydrogen, hydroxy, NR8R9, C (= O) R7, C (= O) OR7, C (= O) NR8R9, C 1-4 alkyl (wherein said C 1-4 alkyl is hydroxy, it is optionally substituted by NR8R9) or a 5-or 6-membered heterocyclic ring (where the 5-or 6-membered heterocyclic ring is C 1-4 alkyl or C (= O) is optionally substituted with R7) or , or R5 and R6, together with the carbon atom to which they are bonded, = CH 2 or 5-or 6-membered heterocycloalkyl to form (wherein the heterocycloalkyl is optionally substituted with C 1-4 alkyl); R7 is hydrogen or C 1-4 alkyl; R8 and R9 are independently, hydrogen or C 1-4 alkyl, or R8 and R9 may, together with the nitrogen atom to which they are bonded, form a click ring between 5- or 6-membered heteroaryl. The present invention further provides pharmaceutical compositions comprising said compounds for use in therapeutics, intermediates for preparing said compounds, pharmaceutical compositions comprising said compounds, methods of treating or ameliorating a benign skin disease or condition using said compounds, And the use of such compounds in the manufacture of medicaments. |