| abstract |
The present invention relates to a soluble variant of Treponema pallidum antigen 47 (TpN47 antigen) comprising at least domain B of a complete TpN47 protein molecule, or at least domains A and B, and optionally domain D, wherein domain C of TpN47 351). ≪ / RTI > The TpN47 antigen can be fused to a chaperone. Furthermore, the present invention encompasses DNA encoding such antigens, methods of producing such antigens as well as the use of such antigens in immunodiagnostic assays for detection of antibodies to treponemal valimund in isolated samples. |