| abstract |
The present invention provided herein relates to compositions, methods, delivery devices and kits for restoring or expanding tissue in a subject. The compositions described herein are injectable so that they can be processed in a minimally invasive procedure (e.g., by injection) and / or can be flexibly shaped into tissue void spaces of any shape and / or size and placed in tissue . In some embodiments, the compositions described herein comprise a plurality of silk fibroin particles, which can maintain their original volume in tissue for a period of time. The composition may be used, for example, as a filler to replace tissue void space for tissue repair and / or enlargement, or as a scaffold to aid tissue regeneration and / or reconstruction. In some embodiments, the compositions described herein may be used for soft tissue repair or enlargement. |