| abstract |
The present invention provides novel compounds (I) and medicaments containing them, especially anti-HIV drugs, as well as their processes and intermediates, which have antiviral activity, in particular HIV integrase inhibitory activity. The compound (I) Wherein Z 1 is NR 4 ; R < 4 > is hydrogen or lower alkyl; X is a single bond, a heteroatom group selected from O, S, SO, SO 2 and NH (each lower alkylene or lower alkenylene may be interrupted by the heteroatom); R 2 is substituted or unsubstituted aryl; R 3 is hydrogen, halogen, hydroxy, substituted or unsubstituted lower alkyl, etc .; And R 4 and Z 2 together form a ring to form a polycyclic compound such as a tricyclic or tetracyclic compound. |