| abstract |
The present invention relates to a substance for restoring normal co-expression and interaction between a LOX protein and a NRAGE protein. In particular, the present invention relates to compositions that modulate the interaction between the LOX protein and the NRAGE protein to regulate the balance between the phenomena of cell proliferation, differentiation and apoptosis, especially when the interaction between the LOX protein and the NRAGE protein is absent or altered The invention relates to the use of an effective amount of one or more substances to modulate the expression and / or activity of LOX having the sequence of SEQ ID NO: 1 and / or to modulate the expression and / or activity of NRAGE having the sequence of SEQ ID NO: 2 . The present invention relates to a method for the treatment and / or prophylaxis of skin aging, squamous cell, graft-versus-host reaction (GVH), eczema, psoriasis and basal cell or cell cancer, especially epithelial cancer, I will. |