abstract |
The present inventors have found that, in a living body to which an antigen-binding molecule containing an FcRn binding domain having binding activity to FcRn under the conditions of an antigen binding domain and a pH neutral domain, in which the binding activity to an antigen is changed according to the ion concentration condition, It was found that an immune response to the antigen was induced. The present inventors have also found that, in a living body to which an antigen-binding molecule containing an FcRn binding domain having binding activity to FcRn under the conditions of an antigen binding domain and a pH neutral domain, , An immune response to the antigen is induced, and at the same time, it has an injury or proliferation inhibitory action against foreign species expressing an antigen to which the antigen-binding molecule binds and cancer cells. |