| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56820bbb13a42311271e147869a36d30 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 |
| filingDate |
2013-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7587655370df8e8941c8e19392fd1bc6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b902cdae14443436e24afc4e8c9bc5c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_314fccafa81d6f0b10bddb87eb59bc90 |
| publicationDate |
2014-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20140067944-A |
| titleOfInvention |
CH3 domain mutant pair inducing heterodimeric high efficiency formation of antibody heavy chain constant region, its preparation method, and use |
| abstract |
The present invention relates to a pair of antibody CH3 domain mutants in which a mutation is induced in the CH3 domain in order to increase the yield of heterologous antibody heavy chain constant region formation of an antibody, a production method and use thereof, and more specifically, Replacing the amino acid residues that induce the formation of homologous duplexes by electrostatic interactions between the respective CH3 domains with amino acid residues that selectively induce selective spatial complementary hydrophobic bond formation and replacing the amino acid residues with no interaction between CH3 domains with long- A CH3 domain heterodimer and a heterologous duplex heavy chain constant domain (Fc) pair comprising the CH3 domain heterodimer, wherein the CH3 domain heterodimer is preferred to combine with the step of selectively substituting the amino acid residue for electrostatic bond formation; Lt; / RTI > The CH3 domain heterozygote according to the present invention not only forms a heterozygous heavy chain constant region at a high yield of 90 to 95% or more, but also has excellent thermal stability, and is a heterodimeric heavy chain constant region containing the CH3 domain heterodimer The double-specific monoclonal antibody recognizing two kinds of antigens simultaneously can be constructed. The CH3 domain heterodimer of the present invention and the bispecific antibody or antibody constant region fusion protein comprising the CH3 domain heterodimer of the present invention can be used as a target antigen And can be usefully applied for the treatment or prevention of diseases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018026942-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017065484-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286311-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459367-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023085779-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021246720-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11155639-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10800825-B2 |
| priorityDate |
2012-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |