http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20140066783-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2012-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37477eca877135f595b9720679b93243 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfb9adeae3ae481ae7ddd2b27bf9af48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e0bdc706904ffcb6be7e6e76829ac71 |
| publicationDate | 2014-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20140066783-A |
| titleOfInvention | Diagnosis of response to epithelial or mesenchymal phenotype and EGFR kinase inhibitor in tumor or tumor cells. |
| abstract | The present invention provides a method for determining the epithelial and mesenchymal phenotype of a tumor and for predicting whether tumor growth is susceptible or resistant to treatment with an EGFR inhibitor. In particular, the presence or absence of methylation of the DNA at the CpG site in one or more genes selected from the group consisting of CLDN7, HOXC4, CP2L3, TBCD, ESPR1, GRHL2, ERBB2, and C20orf55 is indicative of tumor growth for inhibition by EGFR kinase inhibitors And / or as a marker of the mesenchymal phenotype in tumor cells to identify cancer patients likely to be treated with EGFR inhibitors. The presence or absence of DNA methylation at the CpG site in one or more genes selected from the group consisting of PCDH8, PEX5L, GALR1, and ZEB2 is provided as a marker of epithelial phenotype of tumor cells. |
| priorityDate | 2011-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 467.