| abstract |
The present invention relates to substituted 2- (chroman-6-yloxy) -thiazoles of formula I: Formula I In the formula (I) Ar, R2, R3 and R4 are as defined in the claims. The compounds of formula I are inhibitors of the sodium-calcium exchanger (NCX), in particular of the first subtype sodium-calcium exchanger (NCX1), and have inhibitory effects on intracellular calcium homeostasis, for example arrhythmia, heart failure and stroke It is suitable for the treatment of various disorders. The present invention also relates to a process for the preparation of a compound of formula (I), the use of said compound as a medicament, and a pharmaceutical composition comprising said compound. |